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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90AB2P
All Species:
40
Human Site:
S244
Identified Species:
67.69
UniProt:
Q58FF8
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q58FF8
NP_031381
381
44349
S244
H
L
A
V
R
Y
F
S
V
E
E
Y
V
S
R
Chimpanzee
Pan troglodytes
A5A6K9
733
84754
S331
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
Rhesus Macaque
Macaca mulatta
XP_001098219
597
68451
K341
R
E
M
L
Q
Q
S
K
I
L
K
Y
V
S
R
Dog
Lupus familis
XP_857093
509
59005
S256
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
Cat
Felis silvestris
Mouse
Mus musculus
P11499
724
83307
S322
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
Rat
Rattus norvegicus
P34058
724
83263
S322
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518700
789
90657
S414
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
Chicken
Gallus gallus
Q04619
725
83409
S323
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
Frog
Xenopus laevis
NP_001086624
722
82939
S320
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
Zebra Danio
Brachydanio rerio
O57521
725
83339
S321
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
S315
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
Honey Bee
Apis mellifera
XP_395168
718
82735
S318
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
S301
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51818
699
80034
S301
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
41.6
51.4
58.7
N.A.
47.2
47.5
N.A.
42.4
44.8
45
43.7
N.A.
38.4
38.1
36.1
N.A.
Protein Similarity:
100
47.3
55.7
67.5
N.A.
49.8
50
N.A.
45.2
48.5
48.4
48.6
N.A.
45.1
44.4
45.1
N.A.
P-Site Identity:
100
53.3
26.6
53.3
N.A.
53.3
53.3
N.A.
53.3
53.3
53.3
53.3
N.A.
53.3
53.3
53.3
N.A.
P-Site Similarity:
100
73.3
53.3
73.3
N.A.
73.3
73.3
N.A.
73.3
73.3
73.3
73.3
N.A.
73.3
73.3
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
34
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
43.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
93
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
8
0
0
0
0
0
0
0
93
8
0
0
86
0
% E
% Phe:
0
0
0
0
0
0
93
0
0
0
0
0
0
0
86
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
86
0
0
0
0
% G
% His:
93
0
0
0
0
86
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
86
0
0
8
0
0
8
0
0
0
0
% K
% Leu:
0
93
0
8
0
0
0
0
0
8
0
0
86
0
0
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
8
0
0
0
0
0
86
0
0
0
% Q
% Arg:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
15
% R
% Ser:
0
0
0
0
0
0
8
93
0
0
0
0
0
15
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
93
0
0
0
0
93
0
0
0
15
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
15
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _